Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.39 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | SORD | Q00796 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262890 | 0.88 | HTR1A (0.42) | HTR1ADRD2HTR2ADRD3HCAR2 | |
| SCHEMBL2185569 | 0.79 | TSHR (0.47) | PHGDH | |
| SCHEMBL5264521 | 0.79 | MAPT (0.46) | HTR1ADRD2HTR2ADRD3SORD | |
| SCHEMBL2187049 | 0.79 | KDM4E (0.41) | — | |
| SCHEMBL5262815 | 0.77 | NFKB1 (0.52) | HTR1ADRD2HTR2ADRD3SORD | |
| SCHEMBL3061483 | 0.77 | F10 (0.38) | — | |
| SCHEMBL5265670 | 0.75 | HSD11B1 (0.43) | HTR1ADRD2HTR2ADRD3HCAR2 | |
| SCHEMBL2186770 | 0.69 | ALDH1A1 (0.44) | — | |
| SCHEMBL2187194 | 0.68 | TSHR (0.49) | — | |
| SCHEMBL2187222 | 0.67 | TRPC3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1834954-A1 | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) | 4SC AG (DE) | 2007-09-19 | — | — | EP | disclosed |