Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261840 | 0.88 | HTR1A (0.39) | HTR1ADRD2HTR2ADRD3HCAR2 | |
| SCHEMBL2186770 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TRPC3TRPC6 | |
| SCHEMBL2187222 | 0.79 | TRPC3 (0.38) | USP2ALDH1A1TRPC3TRPC6 | |
| SCHEMBL5262815 | 0.79 | NFKB1 (0.52) | HTR1ADRD2HTR2ADRD3HCAR2 | |
| SCHEMBL5265670 | 0.78 | HSD11B1 (0.43) | HTR1ADRD2HTR2ADRD3HCAR2 | |
| SCHEMBL5264521 | 0.78 | MAPT (0.46) | HTR1ADRD2HTR2ADRD3ALDH1A1 | |
| SCHEMBL2187194 | 0.77 | TSHR (0.49) | ALDH1A1 | |
| SCHEMBL2188215 | 0.77 | HCRTR1 (0.45) | ALDH1A1TRPC3TRPC6 | |
| SCHEMBL5316067 | 0.76 | TRPC3 (0.40) | USP2ALDH1A1TRPC3TRPC6 | |
| SCHEMBL27709468 | 0.76 | POLB (0.43) | USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1834954-A1 | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) | 4SC AG (DE) | 2007-09-19 | — | — | EP | disclosed |