Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PLEC | Q15149 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29468013 | 0.85 | MAPT (0.41) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL13073780 | 0.85 | ALDH1A1 (0.49) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL15636043 | 0.82 | KDM4E (0.43) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL5264421 | 0.81 | MITF (0.49) | JAK2KDM4EALDH1A1GAAMAPT | |
| SCHEMBL5264748 | 0.81 | RAB9A (0.51) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL688069 | 0.81 | MAP2K2 (0.46) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL23073616 | 0.81 | KDM4E (0.64) | JAK2KDM4EALDH1A1GAAMAPT | |
| SCHEMBL5265322 | 0.80 | LIPC (0.50) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL28137209 | 0.79 | MKNK1 (0.46) | JAK2JAK3AGTR1KDM4EALDH1A1 | |
| SCHEMBL7454843 | 0.78 | CSF1R (0.46) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |