Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 7/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PLEC | Q15149 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPRA | P18433 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PTPRE | P23469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3898806 | 0.84 | PTPRC (0.60) | MAP2K2MAP2K1KDM4EALDH1A1GAA | |
| SCHEMBL5264748 | 0.83 | RAB9A (0.51) | MAP2K2MAP2K1KDM4EALDH1A1GAA | |
| SCHEMBL5264421 | 0.83 | MITF (0.49) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL6706077 | 0.82 | KDM4E (0.64) | MAP2K2MAP2K1KDM4EALDH1A1GAA | |
| SCHEMBL5261897 | 0.81 | JAK2 (0.46) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL5262043 | 0.79 | ALDH1A1 (0.45) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL5265322 | 0.78 | LIPC (0.50) | KDM4EALDH1A1GAAMAPTTHRB | |
| SCHEMBL3441356 | 0.77 | AGTR1 (0.54) | KDM4EALDH1A1HPGDMKNK1MKNK2 | |
| SCHEMBL5262599 | 0.76 | RAB9A (0.70) | KDM4EALDH1A1GAAMAPTRAB9A | |
| SCHEMBL689300 | 0.76 | GPR35 (0.49) | MAP2K2MAP2K1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |