Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198912 | 0.87 | ALOX5 (0.41) | PDK2ALOX5MAOBTAAR1PGR | |
| SCHEMBL2428524 | 0.78 | KIF11 (0.37) | — | |
| SCHEMBL2053317 | 0.77 | TTR (0.42) | TDP2MEN1HPGDKMT2AESR2 | |
| SCHEMBL15637460 | 0.76 | AHR (0.44) | PDK2MAPTHPGD | |
| SCHEMBL2431244 | 0.75 | PDK2 (0.42) | PDK2PGR | |
| SCHEMBL15286936 | 0.75 | ALOX5 (0.38) | PDK2TDP2ALOX5MEN1GAA | |
| SCHEMBL2430768 | 0.74 | NT5E (0.43) | PDK2TAAR1ESR2NT5E | |
| SCHEMBL15637441 | 0.74 | ESR1 (0.30) | ESR2 | |
| SCHEMBL15638417 | 0.73 | AR (0.38) | PDK2NT5E | |
| SCHEMBL2051091 | 0.73 | HSD11B1 (0.35) | PDK2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814863-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | AstraZeneca AB (SE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052190-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |