Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261544 | 0.81 | TLR7 (0.52) | TLR7MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5263362 | 0.78 | KMT2A (0.41) | S1PR3S1PR1MEN1KMT2ARAB9A | |
| SCHEMBL5262360 | 0.78 | CNR1 (0.52) | — | |
| SCHEMBL5266049 | 0.77 | RAB9A (0.60) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5263458 | 0.77 | L3MBTL1 (0.42) | FFAR2MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5261775 | 0.77 | NSD2 (0.52) | MEN1KMT2AP2RX7ALDH1A1LMNA | |
| SCHEMBL5262392 | 0.77 | SLC6A9 (0.53) | FFAR2MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5260011 | 0.77 | EGLN1 (0.41) | S1PR3S1PR1MEN1KMT2ARAB9A | |
| SCHEMBL5262774 | 0.76 | SLC6A9 (0.54) | MEN1KMT2ARAB9ASMN1; SMN2P2RX7 | |
| SCHEMBL5261011 | 0.76 | ALDH1A1 (0.47) | MEN1KMT2ARAB9ASMN1; SMN2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |