Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.48 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262900 | 0.93 | NSD2 (0.45) | NSD2PABPC1EIF4HMEN1KMT2A | |
| SCHEMBL5367653 | 0.83 | P2RX7 (0.49) | MEN1KMT2AANO1P2RX7ALDH1A1 | |
| SCHEMBL5263458 | 0.81 | L3MBTL1 (0.42) | PABPC1EIF4HMEN1KMT2AL3MBTL1 | |
| SCHEMBL5264063 | 0.80 | PIM1 (0.44) | P2RX7 | |
| SCHEMBL5262202 | 0.80 | TRPV1 (0.45) | P2RX7 | |
| SCHEMBL5260376 | 0.79 | CNR1 (0.49) | NSD2PABPC1EIF4HMEN1KMT2A | |
| SCHEMBL5261544 | 0.78 | TLR7 (0.52) | MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL5261739 | 0.78 | NPC1 (0.61) | P2RX7ALDH1A1HPGD | |
| SCHEMBL5262364 | 0.77 | TLR7 (0.43) | MEN1KMT2AP2RX7ALDH1A1LMNA | |
| SCHEMBL5266049 | 0.75 | RAB9A (0.60) | MEN1KMT2AL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |