Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 5/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213183 | 0.90 | SIGMAR1 (0.47) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Urea SCHEMBL8151835 | 0.89 | RXRA (0.46) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL8159676 | 0.89 | SIGMAR1 (0.46) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Phosphine SCHEMBL5925750 | 0.89 | SIGMAR1 (0.46) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Bromide SCHEMBL4618934 | 0.89 | SIGMAR1 (0.46) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Iodide SCHEMBL9192873 | 0.89 | SIGMAR1 (0.46) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9190644 | 0.89 | SIGMAR1 (0.48) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Sulfuric Acid SCHEMBL11708924 | 0.84 | RXRA (0.44) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Ethylene Glycol SCHEMBL10592333 | 0.84 | SIGMAR1 (0.44) | RXRARXRBRXRGSIGMAR1ALDH1A1 | |
| Urethane SCHEMBL9284788 | 0.82 | RXRA (0.41) | RXRARXRBRXRGSIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1815861-A2 | Ionene polymers and their use as antimicrobial agents | Geltex Pharmaceuticals, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20070025954-A1 | Ionene polymers and their use as antimicrobial agents | FITZPATRICK RICHARD J | 2007-02-01 | — | — | US | disclosed |
| US-20060002888-A1 | Polyionenes for treating infections associated with cystic fibrosis | GENZYME CORPORATION (US) | 2006-01-05 | — | — | US | disclosed |
| US-20060002889-A1 | Polyionene polymers with hydrolyzable linkages | GENZYME CORPORATION (US) | 2006-01-05 | — | — | US | disclosed |
| US-6955806-B2 | Ionene polymers and their use as antimicrobial agents | GENZYME CORPORATION (US) | 2005-10-18 | — | — | US | disclosed |
| WO-2004045629-A1 | POLYIONENES FOR TREATING INFECTIONS ASSOCIATED WITH CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |
| WO-2004046223-A2 | POLYIONENE POLYMERS WITH HYDROLYZABLE LINKAGES | GENZYME CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |
| EP-1372675-A2 | IONENE POLYMERS AND THEIR USE AS ANTIMICROBIAL AGENTS | Geltex Pharmaceuticals, Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20030031644-A1 | Ionene polymers and their use as antimicrobial agents | GELTEX PHARMACEUTICALS, INC. (US) | 2003-02-13 | — | — | US | disclosed |
| US-20030021761-A1 | Ionene polymers and their use in treating mucositis | GELTEX PHARMACEUTICALS, INC. (US) | 2003-01-30 | — | — | US | disclosed |
| WO-2002080939-A2 | IONENE POLYMERS AND THEIR USE AS ANTIMICROBIAL AGENTS | GENZYME CORPORATION (US) | 2002-10-17 | — | — | WO | disclosed |
| WO-2002056895-A2 | IONENE POLYMERS AND THEIR USE IN TREATING MUCOSITIS | GENZYME CORPORATION (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030031644-A1 | Ionene polymers and their use as antimicrobial agents | PIGS, PCNA, ELANE | RXRA 4842/4885RXRB 4874/4885RXRG 4827/4885 |
| US-20060002889-A1 | Polyionene polymers with hydrolyzable linkages | POLI, IDE, MGAM | RXRA 4136/4885RXRB 4538/4885RXRG 4018/4885 |
| US-20060002888-A1 | Polyionenes for treating infections associated with cystic fibrosis | CFTR, ELANE, POLI | RXRA 3118/4885RXRB 3338/4885RXRG 3046/4885 |
| US-20070025954-A1 | Ionene polymers and their use as antimicrobial agents | PIEZO1, PIGS, PCNA | RXRA 4809/4885RXRB 4858/4885RXRG 4799/4885 |
| US-20030021761-A1 | Ionene polymers and their use in treating mucositis | ELANE, PIGS, MRE11 | RXRA 2608/4885RXRB 3362/4885RXRG 2385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.