Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013373 | 0.82 | HCAR2 (0.48) | GLAHCAR2CHRM2CHRM1CHRM3 | |
| SCHEMBL23601799 | 0.82 | HCAR2 (0.48) | GLAHCAR2CHRM2CHRM1CHRM3 | |
| SCHEMBL5262282 | 0.78 | MTNR1A (0.44) | PTGESALDH1A1MTNR1AMTNR1BSLC6A2 | |
| SCHEMBL7783953 | 0.77 | ALDH1A1 (0.42) | PTGESALDH1A1MTNR1AMTNR1BSLC6A2 | |
| SCHEMBL10515353 | 0.76 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM3ALDH1A1SLC6A2 | |
| SCHEMBL5229233 | 0.76 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM3ALDH1A1SLC6A2 | |
| SCHEMBL1812242 | 0.76 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM3ALDH1A1SLC6A2 | |
| SCHEMBL31279443 | 0.76 | RIPK1 (0.54) | GLAHCAR2PTGESCHRM2CHRM1 | |
| SCHEMBL38656959 | 0.74 | HCAR2 (0.41) | GLAHCAR2PTGESALDH1A1AAK1 | |
| SCHEMBL3051941 | 0.74 | ALDH1A1 (0.46) | HCAR2CHRM2CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |