Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6414189 | 1.00 | SIGMAR1 (0.51) | SIGMAR1CTRB1ATMAAK1PTGES | |
| SCHEMBL10305326 | 0.87 | CTRB1 (0.56) | CTRB1ATMNPC1RAB9ACTSK | |
| SCHEMBL13534727 | 0.86 | NPC1 (0.65) | CTRB1ATMNPC1RAB9ACTSK | |
| SCHEMBL4033719 | 0.86 | NPC1 (0.65) | CTRB1ATMNPC1RAB9ACTSK | |
| SCHEMBL5122829 | 0.85 | ALDH1A1 (0.59) | CTSKCTSLCTSSCTSB | |
| SCHEMBL16224709 | 0.85 | ALDH1A1 (0.59) | CTSKCTSLCTSSCTSB | |
| SCHEMBL2985968 | 0.85 | ALDH1A1 (0.52) | CTRB1ATMNPC1RAB9ACTSK | |
| SCHEMBL22636059 | 0.85 | TYR (0.56) | CTRB1CTSKCTSLCTSSCTSB | |
| SCHEMBL22636060 | 0.85 | TYR (0.56) | CTRB1CTSKCTSLCTSSCTSB | |
| SCHEMBL13536730 | 0.85 | ITGB3 (0.55) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |