Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372476 | 0.69 | LMNA (0.49) | LMNATDP1SMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL7787482 | 0.67 | GABRA1 (0.44) | MAPK1HPGDTSHRLMNASMN1; SMN2 | |
| SCHEMBL4942619 | 0.67 | PTGDR2 (0.44) | MAPK1LMNAMEN1KMT2A | |
| SCHEMBL5263997 | 0.67 | MEN1 (0.47) | MAPK1LMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL23275495 | 0.66 | SETDB1 (0.47) | HPGDHTTSMN1; SMN2L3MBTL1P2RX7 | |
| SCHEMBL21606818 | 0.66 | ALOX15 (0.36) | MAPK1HPGDTSHRLMNATDP1 | |
| SCHEMBL12479615 | 0.66 | MAPK1 (0.56) | MAPK1TDP1MAPTRAB9AKDM4E | |
| SCHEMBL23100740 | 0.65 | SMN1; SMN2 (0.56) | TSHRLMNASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL23100741 | 0.65 | SMN1; SMN2 (0.56) | TSHRLMNASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL27229953 | 0.65 | FPR2 (0.45) | HPGDL3MBTL1P2RX7MAPTAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781662-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | Pfizer, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018725-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-02-23 | — | — | WO | disclosed |