Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 6/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473953 | 0.83 | MEN1 (0.39) | MEN1KMT2AGAAPKMALDH1A1 | |
| SCHEMBL3372477 | 0.70 | HDAC1 (0.58) | MEN1KMT2APKMTAS2R14ALDH1A1 | |
| SCHEMBL4472606 | 0.69 | SLC6A4 (0.46) | MEN1KMT2AGAAALDH1A1LMNA | |
| SCHEMBL1235305 | 0.69 | LMNA (0.41) | MEN1KMT2APKMALDH1A1LMNA | |
| SCHEMBL7787482 | 0.68 | GABRA1 (0.44) | ALDH1A1LMNAPOLBNPSR1SMN1; SMN2 | |
| SCHEMBL4942619 | 0.68 | PTGDR2 (0.44) | MEN1KMT2ALMNANPSR1MAPK1 | |
| SCHEMBL5263995 | 0.67 | MAPK1 (0.44) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL1337014 | 0.66 | PKM (0.42) | MEN1KMT2APKMTAS2R14ALDH1A1 | |
| SCHEMBL28208196 | 0.66 | HDAC1 (0.64) | PKMHDAC1HDAC6 | |
| SCHEMBL1581656 | 0.65 | PTGDR2 (0.47) | MEN1KMT2AALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781662-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | Pfizer, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018725-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-02-23 | — | — | WO | disclosed |