SCHEMBL5264

SCHEMBL5264

COc1ccc(N2CCC3(CC=CCC3)C2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 10/20 0.46
USP2 O75604 6/20 0.46
SMN1; SMN2 Q16637 6/20 0.46
ALDH1A1 P00352 6/20 0.46
HIF1A Q16665 5/20 0.46
CYP2C19 P33261 4/20 0.46
CYP1A2 P05177 4/20 0.46
TSHR P16473 3/20 0.46
HPGD P15428 2/20 0.46
CYP2C9 P11712 6/20 0.44
MAPK1 P28482 4/20 0.44
CYP2D6 P10635 4/20 0.44
KMT2A Q03164 3/20 0.44
HSD17B10 Q99714 3/20 0.44
MEN1 O00255 2/20 0.44
TP53 P04637 1/20 0.44
HTR3E A5X5Y0 1/20 0.43
HTR3B O95264 1/20 0.43
ADRB1 P08588 1/20 0.43
HTR3A P46098 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23412145 0.77 ADRB1 (0.61) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
Hydrochloric Acid SCHEMBL23411807 0.75 ADRB1 (0.59) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
Hydrochloric Acid SCHEMBL23411806 0.74 HTR3E (0.58) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
SCHEMBL1426554 0.74 USP2 (0.56) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
SCHEMBL4072450 0.73 CYP3A4 (0.63) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
SCHEMBL14996536 0.73 HTR3E (0.51) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
SCHEMBL4072452 0.71 CYP3A4 (0.55) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
SCHEMBL28325666 0.70 HTR3E (0.59) CYP3A4USP2SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL13168435 0.70 DRD2 (0.54) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A
SCHEMBL13131047 0.70 HTR3E (0.47) CYP3A4USP2SMN1; SMN2ALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488493-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. Hoffmann-La Roche AG (CH) 2012-08-22 EP disclosed
WO-2011045292-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-04-21 WO disclosed