Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261544 | 0.85 | TLR7 (0.52) | KDM4EKMT2AMEN1POLBNPC1 | |
| SCHEMBL5262392 | 0.81 | SLC6A9 (0.53) | KMT2AMEN1RAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL5260011 | 0.81 | EGLN1 (0.41) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL5263576 | 0.80 | RAB9A (0.46) | HPGDKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL5266049 | 0.79 | RAB9A (0.60) | CYP1A2HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL5264953 | 0.79 | CCR5 (0.42) | HPGDKMT2AMEN1NPC1RAB9A | |
| SCHEMBL5264331 | 0.78 | LMNA (0.52) | CYP2C19CYP2C9KMT2AMEN1POLB | |
| SCHEMBL13593756 | 0.77 | KDM4E (0.59) | CYP1A2HPGDCYP2C19CYP2C9NPSR1 | |
| SCHEMBL5261548 | 0.77 | RAB9A (0.40) | HPGDKMT2AMEN1POLBNPC1 | |
| SCHEMBL5262488 | 0.77 | SLC6A9 (0.55) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |