Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262774 | 0.87 | SLC6A9 (0.54) | SLC6A9SLC6A5KMT2AGPR139RAB9A | |
| SCHEMBL5262488 | 0.85 | SLC6A9 (0.55) | SLC6A9SLC6A5KMT2AGPR139RAB9A | |
| SCHEMBL5261544 | 0.83 | TLR7 (0.52) | KMT2ARAB9ANPC1TSHRL3MBTL1 | |
| SCHEMBL5264331 | 0.81 | LMNA (0.52) | SLC6A9SLC6A5KMT2ALMNAGPR139 | |
| SCHEMBL5266049 | 0.80 | RAB9A (0.60) | SLC6A9SLC6A5KMT2ABLMLMNA | |
| SCHEMBL5260012 | 0.80 | UTS2R (0.53) | SLC6A9SLC6A5KMT2AGPR139RAB9A | |
| SCHEMBL5262392 | 0.79 | SLC6A9 (0.53) | SLC6A9KMT2ARAB9ASMN1; SMN2TSHR | |
| SCHEMBL4692365 | 0.79 | ALDH1A1 (0.52) | LMNASMN1; SMN2CYP2D6CYP2C9POLB | |
| SCHEMBL5264039 | 0.76 | KMT2A (0.53) | KMT2ALMNAGPR139NFKB1RAB9A | |
| SCHEMBL4692132 | 0.75 | CNR1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |