Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180595 | 0.85 | KAT6A (0.48) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL27534239 | 0.83 | GRM2 (0.45) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL7808087 | 0.83 | GRM2 (0.48) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL1738690 | 0.83 | GRM2 (0.45) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL3997064 | 0.83 | GRM2 (0.48) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL5232319 | 0.83 | DRD2 (0.46) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL2204086 | 0.83 | HTR6 (0.67) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| SCHEMBL13667982 | 0.82 | KEAP1 (0.53) | HTR6ALDH1A1GAAHSD17B10GRM2 | |
| SCHEMBL10180044 | 0.81 | LPL (0.47) | HTR6ALDH1A1GAAHSD17B10DRD2 | |
| Hydrochloric Acid SCHEMBL15741790 | 0.81 | HTR6 (0.65) | HTR6ALDH1A1GAAHSD17B10DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |