Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272564 | 0.83 | NPY4R (0.57) | NPC1SMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL5267757 | 0.82 | KMT2A (0.47) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL5271504 | 0.80 | HPGD (0.53) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5269224 | 0.79 | KDM4E (0.49) | NPC1SMN1; SMN2MAPTRAB9AMEN1 | |
| SCHEMBL5268734 | 0.79 | KDM4E (0.51) | NPC1SMN1; SMN2MAPTRAB9AMEN1 | |
| SCHEMBL5272569 | 0.79 | MAPT (0.58) | NPC1TDP1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL5269702 | 0.78 | EPHX2 (0.49) | NPC1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL5267185 | 0.78 | POLB (0.48) | NPC1SMN1; SMN2MAPTRAB9AMEN1 | |
| SCHEMBL5266006 | 0.78 | RAB9A (0.51) | NPC1SMN1; SMN2MAPTRAB9AMEN1 | |
| SCHEMBL5269236 | 0.77 | MMP2 (0.41) | RAB9AMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |