Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269224 | 0.88 | KDM4E (0.49) | KDM4EPOLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5272569 | 0.88 | MAPT (0.58) | KDM4EPOLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5266006 | 0.86 | RAB9A (0.51) | KDM4EPOLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5267185 | 0.86 | POLB (0.48) | KDM4EPOLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5269702 | 0.82 | EPHX2 (0.49) | KDM4EPOLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5267166 | 0.81 | NPC1 (0.52) | KDM4ERAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL5271648 | 0.81 | KMT2A (0.54) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL5265275 | 0.79 | ALDH1A1 (0.54) | KDM4EPOLBRAB9ASMN1; SMN2MAPT | |
| SCHEMBL5267112 | 0.79 | NPC1 (0.48) | KDM4EPOLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2801325 | 0.76 | ALOX15 (0.48) | RAB9ASMN1; SMN2NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |