Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.45 |
| ▸ | HPD | P32754 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | SOD1 | P00441 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379281 | 0.74 | MAOB (0.67) | MAOBMRGPRX4GSTP1MAOANR4A2 | |
| SCHEMBL2137838 | 0.73 | MRGPRX4 (0.69) | MAOBMRGPRX4GSTP1MAOANR4A2 | |
| SCHEMBL30317738 | 0.72 | MAOB (0.49) | MAOBPRKDCATMBRD4MRGPRX4 | |
| SCHEMBL5266330 | 0.72 | MAOB (0.49) | MAOBPRKDCATMBRD4MRGPRX4 | |
| SCHEMBL19389796 | 0.71 | HPD (0.51) | MAOBBRD4HPDMAOANR4A2 | |
| SCHEMBL9214604 | 0.69 | FABP7 (0.51) | MAOBPRKDCATMBRD4MRGPRX4 | |
| SCHEMBL1268719 | 0.69 | MAOB (0.81) | MAOBMAOANR4A2GRM5 | |
| SCHEMBL16346074 | 0.69 | GSTP1 (0.66) | MAOBMRGPRX4GSTP1NR4A2 | |
| SCHEMBL27418806 | 0.69 | MAOB (0.56) | MAOBMAOAGRM5ALDH1A1NPC1 | |
| SCHEMBL7328699 | 0.69 | MAOB (0.69) | MAOBMAOAGRM5ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1596106-B | Use of trifluoroacetyl alkyl-substituted phenyl derivatives, phenol derivatives, and benzoyl derivatives in the treatment and/or prophylaxis of obesity and complications and/or sequelas | SOLVAY PHARM BV | 2011-05-11 | — | — | CN | disclosed |
| EP-1420771-B9 | USE OF TRIFLUOROACETYL ALKYL-SUBSTITUTED PHENYL DERIVATIVES, PHENOL DERIVATIVES, AND BENZOYL DERIVATIVES IN THE TREATMENT AND/OR PROPHYLAXIS OF OBESITY AND ACCOMPANYING DISEASES AND/OR SECONDARY DISEASES | SOLVAY PHARM GMBH (DE) | 2007-10-17 | — | — | EP | disclosed |
| EP-1420771-B1 | USE OF TRIFLUOROACETYL ALKYL-SUBSTITUTED PHENYL DERIVATIVES, PHENOL DERIVATIVES, AND BENZOYL DERIVATIVES IN THE TREATMENT AND/OR PROPHYLAXIS OF OBESITY AND ACCOMPANYING DISEASES AND/OR SECONDARY DISEASES | SOLVAY PHARM GMBH (DE) | 2006-09-06 | — | — | EP | disclosed |
| US-6930207-B2 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment | SOLVAY PHARMACEUTICAL GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| CN-1596106-A | Use of trifluoroacetyl alkyl-substituted phenyl derivatives, phenol derivatives, and benzoyl derivatives in the treatment and/or prophylaxis of obesity and accompanying diseases and/or secondary disea | SOLVAY PHARM GMBH (DE) | 2005-03-16 | — | — | CN | disclosed |
| US-20040214901-A1 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment | SOLVAY PHARMACEUTICALS GMBH (DE) | 2004-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214901-A1 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment | PNLIP, LIPC, CEL | MAOB 334/4885PRKDC 3684/4885ATM 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.