Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264527 | 0.91 | ALOX5 (0.47) | MAOBALOX5P2RY14HRH3BCHE | |
| SCHEMBL6668074 | 0.80 | MAOB (0.54) | MAOBALOX5P2RY14DYRK1BBCHE | |
| SCHEMBL225278 | 0.74 | MAOB (0.61) | MAOBALOX5BCHEFFAR1 | |
| SCHEMBL9405631 | 0.70 | MAOB (0.71) | MAOBBCHEERN1FFAR1 | |
| SCHEMBL791569 | 0.69 | MAOB (1.00) | MAOBBCHEHTR1A | |
| SCHEMBL25876813 | 0.69 | MAOB (0.44) | MAOBHTR1A | |
| SCHEMBL7096339 | 0.69 | L3MBTL1 (0.57) | MAOBDYRK1BBCHEERN1 | |
| SCHEMBL6087375 | 0.69 | NPSR1 (0.58) | MAOBALOX5P2RY14 | |
| SCHEMBL6086702 | 0.69 | MGAM (0.56) | MAOBALOX5P2RY14SLC6A2SLC6A3 | |
| SCHEMBL29561154 | 0.68 | CYP11B1 (0.48) | MAOBALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272471-B1 | NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS | ORGANON NV (NL) | 2007-10-03 | — | — | EP | claimed |
| EP-1272471-B1 | NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS | ORGANON NV (NL) | 2007-10-03 | — | — | EP | disclosed |
| US-6686371-B2 | HAVING AN 11H-BENZO(B)FLUORENE, AN 11H-INDENO-(1,2-B) QUINOLINE, A BENZ(A)ANTHRACENE OR ANALOGOUS SKELETON AND AN AFFINITY FOR THE ESTROGEN RECEPTOR; CONTRACEPTIVES; MENOPAUSAL COMPLAINTS, OSTEOPOROSIS; ANTITUMOR AGENTS | AKZO NOBEL N.V. (NL) | 2004-02-03 | — | — | US | disclosed |
| US-20030144313-A1 | Non-steroidal, tetracylic compounds for estrogen-related treatments | N.V. ORGANON (NL) | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144313-A1 | Non-steroidal, tetracylic compounds for estrogen-related treatments | ESRRA, ESRRB, ESRRG | MAOB 3356/4885ALOX5 1158/4885P2RY14 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.