Sugi Predict

Sugi Predict / Compounds / SCHEMBL526864

SCHEMBL526864

SCHEMBL526864

CC(C)(C)OC(=O)Nc1cccc(O)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 1/20 0.60
▸ ALDH1A1 P00352 1/20 0.59
▸ CYP1A2 P05177 1/20 0.59
▸ RXFP1 Q9HBX9 1/20 0.52
▸ KMT2A Q03164 3/20 0.51
▸ MEN1 O00255 2/20 0.51
▸ HDAC3 O15379 1/20 0.51
▸ HDAC1 Q13547 1/20 0.51
▸ HDAC2 Q92769 1/20 0.51
▸ HDAC8 Q9BY41 1/20 0.51
▸ HDAC6 Q9UBN7 1/20 0.51
▸ NLRP3 Q96P20 3/20 0.50
▸ CYP17A1 P05093 1/20 0.50
▸ KAT6A Q92794 1/20 0.49
▸ MMP1 P03956 1/20 0.49
▸ MMP2 P08253 1/20 0.49
▸ MMP9 P14780 1/20 0.49
▸ EPHX2 P34913 1/20 0.48
▸ RAB9A P51151 3/20 0.48
▸ NPC1 O15118 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29764154 1.00 SYK (0.60) SYKALDH1A1CYP1A2RXFP1KMT2A
SCHEMBL29029431 0.90 HDAC3 (0.56) SYKRXFP1HDAC3HDAC1HDAC2
SCHEMBL10845090 0.84 AURKB (0.53) SYKALDH1A1CYP1A2NLRP3RAB9A
SCHEMBL8191789 0.84 RXFP1 (0.50) SYKALDH1A1RXFP1KMT2AMEN1
SCHEMBL29991501 0.83 HSD17B10 (0.59) ALDH1A1RXFP1KMT2AMEN1HDAC3
SCHEMBL8966117 0.83 HSD17B10 (0.59) ALDH1A1RXFP1KMT2AMEN1HDAC3
SCHEMBL730506 0.83 HDAC3 (0.51) SYKRXFP1HDAC3HDAC1HDAC2
SCHEMBL6869447 0.83 LMNA (0.51) SYKCYP1A2RXFP1HDAC3HDAC1
SCHEMBL29355426 0.82 ALDH1A1 (0.67) ALDH1A1CYP1A2KMT2AMEN1NLRP3
SCHEMBL8017782 0.82 ALDH1A1 (0.67) ALDH1A1CYP1A2KMT2AMEN1NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 430 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115197130-B Aryl urea derivative and preparation method and application thereof 安徽医科大学 2023-06-27 — — CN claimed
CN-115197130-A Aryl urea derivative and preparation method and application thereof 安徽医科大学 2022-10-18 — — CN claimed
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECH LIMITED (GB) 2026-05-21 — — US disclosed
EP-4688772-A1 BIARYL DERIVATIVES AND RELATED USES Moma Therapeutics, Inc. (US) 2026-02-11 — — EP disclosed
US-20260021192-A1 PROTEINS HAVING A COVALENT WARHEAD TOPAZ THERAPEUTICS INC (US) 2026-01-22 — — US disclosed
US-20260015360-A1 BIARYL DERIVATIVES AND RELATED USES MOMA THERAPEUTICS, INC. 2026-01-15 — — US disclosed
US-20250353874-A1 GLUCOCORTICOID RECEPTOR AGONISTS LILLY CO ELI (US) 2025-11-20 — — US disclosed
WO-2025231152-A1 COMPOUNDS AND METHODS FOR RESTORING BETA-ADRENERGIC RECEPTOR FUNCTION THE CLEVELAND CLINIC FOUNDATION (US) 2025-11-06 — — WO disclosed
EP-4007752-B1 KIF18A INHIBITORS AMGEN INC (US) 2025-09-24 — — EP disclosed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 — — EP disclosed
US-12404298-B2 Glucocorticoid receptor agonists ELI LILLY AND COMPANY (US) 2025-09-02 — — US disclosed
US-6221898-B1 ANTICOAGULANTS ASTRA AKTIEBOLAG (SE) 2001-04-24 — — US disclosed
CN-1246850-A 1,5-benzodiazepine derivatives ZERIA PHARM CO LTD (JP) 2000-03-08 — — CN disclosed
EP-0917528-A1 NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS Astra Aktiebolag (SE) 1999-05-26 — — EP disclosed
EP-0880502-A1 AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS ZENECA LIMITED (GB) 1998-12-02 — — EP disclosed
US-5776929-A GASTRIN INHIBITOR; GASTROINTESTINAL DISORDERS SHIONOGI & CO., LTD. (JP) 1998-07-07 — — US disclosed
WO-1998001422-A1 NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS ASTRA AKTIEBOLAG (SE) 1998-01-15 — — WO disclosed
WO-1997028129-A1 AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS ZENECA LIMITED (GB) 1997-08-07 — — WO disclosed
CN-1143362-A Novel benzodizaepine derivative SHIONOGI & CO (JP) 1997-02-19 — — CN disclosed
EP-0728748-A1 NOVEL BENZODIAZEPINE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1996-08-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER EGFR, KRAS, O60361 SYK 2935/4885ALDH1A1 999/4885CYP1A2 1430/4885
US-20260015360-A1 BIARYL DERIVATIVES AND RELATED USES POLB, POLA1, POLN SYK 4688/4885ALDH1A1 824/4885CYP1A2 558/4885
US-12404298-B2 Glucocorticoid receptor agonists NR3C1, NR3C2, MC2R SYK 677/4885ALDH1A1 3227/4885CYP1A2 459/4885
US-20250353874-A1 GLUCOCORTICOID RECEPTOR AGONISTS NR3C1, NR3C2, MC2R SYK 677/4885ALDH1A1 3227/4885CYP1A2 459/4885
US-20260021192-A1 PROTEINS HAVING A COVALENT WARHEAD RIOX2, ORC3, DCLRE1A SYK 4512/4885ALDH1A1 3714/4885CYP1A2 4723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.