Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268891 | 0.95 | KDM4E (0.41) | FAAHNTRK1ALDH1A1NPC1RAB9A | |
| SCHEMBL5270250 | 0.91 | TSPO (0.42) | ALDH1A1NPC1RAB9AKDM4EHPGD | |
| SCHEMBL5268584 | 0.87 | GABRA1 (0.41) | NTRK1ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL5269452 | 0.87 | MGLL (0.44) | ALDH1A1NPC1RAB9AKDM4EHPGD | |
| SCHEMBL5272397 | 0.86 | SMN1; SMN2 (0.42) | NTRK1SLC2A2NPC1RAB9A | |
| SCHEMBL5271977 | 0.86 | FAAH (0.40) | FAAHALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL5273077 | 0.85 | ALDH1A1 (0.42) | NTRK1SLC2A2ALDH1A1NPC1RAB9A | |
| SCHEMBL5271931 | 0.84 | TP53 (0.51) | FAAHNTRK1ALDH1A1NPC1RAB9A | |
| SCHEMBL5271030 | 0.84 | FAAH (0.38) | FAAHALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4259250 | 0.82 | GABRA1 (0.54) | ALDH1A1NPC1RAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | claimed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | claimed |
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | disclosed |