Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5267752 | 0.88 | NPC1 (0.45) | NPC1MMP13HSD17B10MEN1KMT2A | |
| SCHEMBL4258953 | 0.82 | GABRA1 (0.52) | NAMPTNPC1MMP13HSD17B10CYP3A4 | |
| SCHEMBL5268584 | 0.81 | GABRA1 (0.41) | TSHRHSD17B10CYP3A4 | |
| SCHEMBL10533394 | 0.79 | LMNA (0.42) | NPC1THRBMEN1KMT2A | |
| SCHEMBL5270748 | 0.79 | NTRK1 (0.41) | HSD17B10CYP3A4 | |
| SCHEMBL5273077 | 0.79 | ALDH1A1 (0.42) | TSHRNPC1HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL5273489 | 0.78 | NPC1 (0.46) | NAMPTNPC1MEN1KMT2A | |
| SCHEMBL5268891 | 0.78 | KDM4E (0.41) | NPC1HSD17B10CYP3A4 | |
| SCHEMBL5271931 | 0.78 | TP53 (0.51) | NPC1MEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL5268657 | 0.78 | FAAH (0.43) | TSHRNPC1HSD17B10CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | disclosed |