Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553865 | 0.77 | SMN1; SMN2 (0.45) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL8553868 | 0.77 | SMN1; SMN2 (0.45) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL21504070 | 0.76 | TSHR (0.43) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL21504066 | 0.75 | SMN1; SMN2 (0.48) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL5799729 | 0.75 | HTT (0.46) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL21504068 | 0.73 | L3MBTL1 (0.42) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL6159138 | 0.73 | HTT (0.44) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL15711280 | 0.73 | HTT (0.44) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL3919626 | 0.73 | HTT (0.44) | HTTTSHRL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL24229764 | 0.72 | HTT (0.39) | HTTTSHRL3MBTL1SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458395-B1 | MEDICAL USE OF GSK3-INHIBITING OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-11-28 | — | — | EP | disclosed |
| US-20050075351-A1 | Use | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | US | disclosed |
| EP-1458395-A1 | NEW USE | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053444-A1 | NEW USE | ASTRAZENECA AB (SE) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075351-A1 | Use | GSK3A, GSK3B, PYGB | HTT 1110/4885TSHR 3909/4885L3MBTL1 4322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.