Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5242061 | 0.81 | KMT2A (0.53) | MTNR1AMTNR1BKMT2AHCRTR2 | |
| SCHEMBL5454057 | 0.80 | ABCB1 (0.54) | MEN1KMT2AALDH1A1HTTKDM4E | |
| SCHEMBL5241961 | 0.80 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL5786435 | 0.72 | GPR183 (0.51) | KMT2AAGTR2ACE | |
| SCHEMBL5789193 | 0.71 | CA2 (0.41) | ADRA1DADRA1BALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7854656 | 0.71 | DRD2 (0.42) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL5466197 | 0.71 | MTNR1A (0.50) | MTNR1AMTNR1BKDM4ECASR | |
| SCHEMBL5786442 | 0.71 | HDAC6 (0.46) | — | |
| SCHEMBL5276997 | 0.70 | CA2 (0.45) | KMT2AAGTR2ALDH1A1KDM4E | |
| SCHEMBL10974666 | 0.69 | ADRA2A (0.98) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |