Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275968 | 0.82 | HSPB1 (0.46) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL3960774 | 0.76 | HSPB1 (0.48) | HSPB1TRPA1ALDH1A1HTTKMT2A | |
| SCHEMBL10456772 | 0.75 | TRPA1 (0.56) | HSPB1TRPA1ALDH1A1EPAS1MAP4K4 | |
| SCHEMBL21129891 | 0.75 | HSPB1 (0.41) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL22809757 | 0.75 | ALDH1A1 (0.44) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL19524123 | 0.74 | ERN1 (0.41) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL5991434 | 0.74 | SCN8A (0.45) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL30159449 | 0.73 | TRPA1 (0.53) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL19563735 | 0.73 | SCN8A (0.46) | HSPB1TRPA1ALDH1A1HTTEPAS1 | |
| SCHEMBL1137695 | 0.73 | PTGER3 (0.58) | ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784390-A2 | SUBSTITUTED BENZOFUSED HETEROCYCLES | Amgen Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006020959-A2 | SUBSTITUTED BENZOFUSED HETEROCYCLES | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |