SCHEMBL5280367

SCHEMBL5280367

CC(OC(=O)CO)c1cc(Cc2cc(C(C)OC(=O)CO)cc(-n3nc4ccccc4n3)c2O)c(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.38
RAB9A P51151 7/20 0.38
KDM4E B2RXH2 8/20 0.38
ALDH1A1 P00352 7/20 0.38
HPGD P15428 5/20 0.38
MAPT P10636 4/20 0.38
TDP1 Q9NUW8 2/20 0.38
POLB P06746 2/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
GPR139 Q6DWJ6 1/20 0.36
LMNA P02545 2/20 0.35
CASP3 P42574 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
LPAR1 Q92633 1/20 0.34
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5276856 0.91 NPC1 (0.37) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL5274123 0.89 NPC1 (0.36) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL6753077 0.88 NPC1 (0.34) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL7737084 0.85 NPC1 (0.37) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL5283156 0.83 NPC1 (0.33) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL20363907 0.81 NPC1 (0.47) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL4444920 0.80 NPC1 (0.46) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL26658010 0.74 NPC1 (0.46) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL22307275 0.74 NPC1 (0.41) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL5280370 0.74 ALOX5 (0.37) NPC1RAB9AKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1125764-B1 TRANSFER MATERIAL, SURFACE-PROTECTIVE SHEET, AND PROCESS FOR PRODUCING MOLDED ARTICLE WITH THESE NISSHA PRINTING (JP) 2007-12-05 EP disclosed
US-6703139-B1 BISBENZOTRIAZOLYLPHENOL COMPOUND AS AN ULTRAVIOLET ABSORBER OTSUKA CHEMICAL CO., LTD. (JP) 2004-03-09 US disclosed
EP-1125764-A1 TRANSFER MATERIAL, SURFACE-PROTECTIVE SHEET, AND PROCESS FOR PRODUCING MOLDED ARTICLE WITH THESE NISSHA PRINTING CO., LTD. (JP) 2001-08-22 EP disclosed
EP-1104790-A1 WEATHER-RESISTANT COMPOSITION, COATING MATERIALS AND MOLDED ARTICLES OTSUKA CHEMICAL COMPANY, LIMITED (JP) 2001-06-06 EP disclosed