Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | ACLY | P53396 | 4/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748251 | 0.87 | ACLY (0.50) | ACLYMDM2RPS6KB1MARS1IDO1 | |
| SCHEMBL5275083 | 0.85 | HDAC3 (0.48) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL5274599 | 0.82 | CNR1 (0.40) | CNR1MEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL5272631 | 0.78 | HTR6 (0.46) | ALDH1A1HTT | |
| SCHEMBL5280864 | 0.73 | SMN1; SMN2 (0.47) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL1748139 | 0.72 | GRN (0.36) | ACLYMDM2ALDH1A1MEN1KMT2A | |
| SCHEMBL5273090 | 0.72 | CCR2 (0.48) | ACLY | |
| SCHEMBL5276755 | 0.72 | CDC7 (0.45) | RPS6KB1IDO1HTTHDAC4 | |
| SCHEMBL1748141 | 0.69 | AURKA (0.44) | RPS6KB1ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL21722883 | 0.68 | HPGD (0.50) | HPGDALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |