Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284618 | 0.81 | RORA (0.60) | ALDH1A1IKBKBHPGDLMNAMEN1 | |
| SCHEMBL3268660 | 0.73 | ITGA1 (0.68) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL6397094 | 0.71 | ALDH1A1 (0.54) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL6392109 | 0.70 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL5291761 | 0.70 | KMT2A (0.49) | ALDH1A1IKBKBHPGDLMNAMEN1 | |
| SCHEMBL8160125 | 0.69 | ALDH1A1 (0.69) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25072430 | 0.68 | HPGD (0.50) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL25315174 | 0.68 | MAPT (0.80) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL17210223 | 0.68 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL5244028 | 0.67 | MYC (0.51) | ALDH1A1IKBKBHPGDLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |