2-Pyrrolidone

2-Pyrrolidone

SCHEMBL3729403

CC(N)=O.O=C1CCCN1

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.68
CRBN Q96SW2 3/20 0.58
FKBP5 Q13451 1/20 0.58
KDM4E B2RXH2 2/20 0.41
GAA P10253 1/20 0.41
POLB P06746 1/20 0.41
LMNA P02545 2/20 0.36
ALOX15 P16050 1/20 0.36
BLM P54132 1/20 0.36
PMP22 Q01453 1/20 0.36
NNMT P40261 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
GFER P55789 1/20 0.35
KMT2A Q03164 1/20 0.34
SIRT2 Q8IXJ6 5/20 0.34
SIRT1 Q96EB6 5/20 0.34
SIRT3 Q9NTG7 5/20 0.34
HSP90AA1 P07900 1/20 0.33
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Caprolactam SCHEMBL1532933 0.91 CRBN (0.67) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL6849688 0.91 OR51E2 (0.75) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL17698402 0.91 OR51E2 (0.75) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL4666153 0.88 OR51E2 (0.71) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL2155488 0.88 OR51E2 (0.71) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL1458792 0.88 OR51E2 (0.58) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL27605240 0.86 OR51E2 (0.68) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL28310048 0.86 OR51E2 (0.68) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL1436788 0.85
2-Pyrrolidone SCHEMBL27520190 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117253651-A High-stability sintered copper paste and preparation method and application thereof 北京工业大学 2023-12-19 CN claimed
CN-115732119-A Metal conductive silver paste and preparation method and application thereof 苏州思尔维纳米科技有限公司 2023-03-03 CN claimed
CN-111411536-B Oxford fabric production process 苏州市登顶纺织有限公司 2022-07-12 CN claimed
CN-111411536-A Oxford fabric production process 苏州市登顶纺织有限公司 2020-07-14 CN claimed
US-20040077709-A1 Neuronal death inhibitors DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-22 US claimed
CN-1368882-A Neuronal death inhibitors DAIICHI SEIYAKU CO (JP) 2002-09-11 CN claimed
EP-1180366-A9 NEURONAL DEATH INHIBITORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-04-24 EP claimed
EP-1180366-A1 NEURONAL DEATH INHIBITORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-02-20 EP claimed
CN-1074933-C Anti-stress, anti-impairment and anti-aging drug and process for manufacturing thereof RIGA D (RO) 2001-11-21 CN claimed
CN-115732119-B Metal conductive silver paste and preparation method and application thereof 苏州思尔维纳米科技有限公司 2025-02-18 CN disclosed
CN-117567689-A Hyperbranched slow-expansion blocking agent and preparation method thereof 中国石油化工股份有限公司 2024-02-20 CN disclosed
US-11866407-B2 Compositions and methods for inhibiting Mpro and PLpro protease activity and for preventing and treating SARS-CoV-2 infection ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-01-09 US disclosed
US-11866407-B2 Compositions and methods for inhibiting Mpro and PLpro protease activity and for preventing and treating SARS-CoV-2 infection ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-01-09 US disclosed
CN-117253651-A High-stability sintered copper paste and preparation method and application thereof 北京工业大学 2023-12-19 CN disclosed
CN-1105357-A Process for synthesizing alpha-pyrrolidone acetamide UNIV BEIJING (CN) 1995-07-19 CN disclosed
CN-1027693-C Novel separation method of clausenamide compounds PHARMACEUTICALS INST CHINESE A (CN) 1995-02-22 CN disclosed
WO-1992014149-A1 APPARATUS AND METHODS FOR USING HEMOZOIN ARIZONA TECHNOLOGY DEVELOPMENT CORPORATION (US) 1992-08-20 WO disclosed
CN-1012172-B Method for separating and extracting novel clausenamide compounds PHARMACOLOGY INST OF CAMS (CN) 1991-03-27 CN disclosed
CN-1049345-A The preparation method of new type amide compound with xanthic surface PHARMACEUTICALS INST CHINESE A (CN) 1991-02-20 CN disclosed
CN-85106973-A Process for the preparation of a novel pharmaceutical composition of sigma-butyrolactams and pharmaceutical use thereof 1987-04-01 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11866407-B2 Compositions and methods for inhibiting Mpro and PLpro protease activity and for preventing and treating SARS-CoV-2 infection ACE2, PREP, ACE OR51E2 4174/4885CRBN 2040/4885FKBP5 724/4885
US-20040077709-A1 Neuronal death inhibitors CASP3, CASP1, AIFM1 OR51E2 3124/4885CRBN 1199/4885FKBP5 2059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.