2-Pyrrolidone

2-Pyrrolidone

SCHEMBL7090022

C=C(C)C(=O)OC.O=C1CCCN1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
OR51E2 Q9H255 1/20 0.52
CRBN Q96SW2 2/20 0.45
FKBP5 Q13451 1/20 0.45
KDM4E B2RXH2 2/20 0.34
GAA P10253 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.33
GFER P55789 1/20 0.33
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.33
TSHR P16473 1/20 0.32
USP2 O75604 1/20 0.30
MAPK1 P28482 1/20 0.30
HTT P42858 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Caprolactam SCHEMBL28170750 0.93 CRBN (0.52) ALDH1A1OR51E2CRBNFKBP5KDM4E
2-Pyrrolidone SCHEMBL8965954 0.87 OR51E2 (0.48) ALDH1A1OR51E2CRBNFKBP5KDM4E
2-Pyrrolidone SCHEMBL5282378 0.83 OR51E2 (0.62) ALDH1A1OR51E2CRBNFKBP5KDM4E
SCHEMBL9078238 0.82 ALDH1A1 (0.56) ALDH1A1CRBNKDM4EMAPTKMT2A
2-Pyrrolidone SCHEMBL28134430 0.82 OR51E2 (0.47) ALDH1A1OR51E2CRBNFKBP5KDM4E
2-Pyrrolidone SCHEMBL8133376 0.82 OR51E2 (0.47) ALDH1A1OR51E2CRBNFKBP5POLB
2-Pyrrolidone SCHEMBL28134431 0.82 OR51E2 (0.47) ALDH1A1OR51E2CRBNFKBP5KDM4E
2-Pyrrolidone SCHEMBL27365042 0.82 OR51E2 (0.47) ALDH1A1OR51E2CRBNFKBP5KDM4E
Methacrylic Acid SCHEMBL183419 0.82 OR51E2 (0.60) ALDH1A1OR51E2CRBNFKBP5KDM4E
2-Pyrrolidone SCHEMBL28258038 0.81 OR51E2 (0.71) ALDH1A1OR51E2CRBNFKBP5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0752625-B1 Copolymers useful as charge injection barrier materials for photoreceptor HEWLETT PACKARD CO (US) 2000-11-15 EP claimed
EP-0752625-A2 Copolymers useful as charge injection barrier materials for photoreceptor Hewlett-Packard Company (US) 1997-01-08 EP claimed
CN-108976441-A A kind of selfreparing growth hydrogel and preparation method for beauty and shaping 成都新柯力化工科技有限公司 2018-12-11 CN disclosed
CN-108367517-A Method for producing the haptic lens with lubricated surface 诺华股份有限公司 2018-08-03 CN disclosed
WO-2018017390-A1 A HAIR CARE COMPOSITION, PROCESS FOR PREPARING THE SAME AND METHOD OF USE THEREOF ISP INVESTMENTS LLC (US) 2018-01-25 WO disclosed
US-9512325-B2 Compositions comprising a reactive monomer and uses thereof ISP INVESTMENTS LLC (US) 2016-12-06 US disclosed
US-20130150481-A1 COMPOSITIONS COMPRISING A REACTIVE MONOMER AND USES THEREOF HERCULES LLC 2013-06-13 US disclosed
CN-101849209-B Composition for forming top anti-reflection film and pattern forming method using the same AZ ELECTRONIC MATERIALS JAPAN 2012-11-28 CN disclosed
CN-101856508-A Novel aquagel tissue filling agent used for ophthalmonogy UNIV TIANJIN 2010-10-13 CN disclosed
CN-101849209-A Composition for forming top anti-reflection film and pattern forming method using the same AZ ELECTRONIC MATERIALS JAPAN 2010-09-29 CN disclosed
US-20030010668-A1 Desiccating container for moisture-sensitive material WEST PHARMACEUTICAL SERVICES, INC. 2003-01-16 US disclosed
US-5494155-A CONTACTING HYDRATABLE XEROGEL POLYMER INTO AQUEOUS SOLUTION OF ABSORBENT SELECTED FROM ACTIVATED CARBON, SILICA GEL AND ORGANIC SOLVENT TO REDUCE CONCENTRATION OF MONOMER AND OLIGOMERS PRESENT AS IMPURITIES PILKINGTON BARNES HIND, INC. (US) 1996-02-27 US disclosed
WO-1996000649-A1 INCORPORATION OF ADSORBENTS DURING EXTRACTION AND/OR HYDRATION OF HYDROGEL MATERIALS PILKINGTON BARNES HIND, INC. (US) 1996-01-11 WO disclosed
US-5294401-A Blood gas exchange TERUMO KABUSHIKI KAISHA (JP) 1994-03-15 US disclosed
EP-0354959-B1 MEMBRANE TYPE ARTIFICIAL LUNG AND PRODUCTION THEREOF TERUMO KABUSHIKI KAISHA (JP) 1993-01-20 EP disclosed
EP-0354959-A1 MEMBRANE TYPE ARTIFICIAL LUNG AND PRODUCTION THEREOF TERUMO KABUSHIKI KAISHA (JP) 1990-02-21 EP disclosed
CN-1005290-B Soft contact optical objective 拜尔公司 1989-09-27 CN disclosed
US-4866148-A CROSSLINKED VINYLPYRROLIDONE, METHYLVINYLACETAMIDE, METHACRYLIC ACID ESTER BAYER AKTIENGESELLSCHAFT (DE) 1989-09-12 US disclosed
CN-1004587-B Contact optical article made from hydrophilic copolymers for biomedical applications 拜尔公司 1989-06-21 CN disclosed
CN-85109093-A Make contact-optical articles with hydrophilic copolymers with biomedical applications 1986-10-08 CN disclosed