Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | SOD1 | P00441 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30358275 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9488681 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL5407250 | 0.85 | KDM4E (0.58) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL11736722 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL16301357 | 0.83 | LMNA (0.68) | ALDH1A1TDP1TRPV6LMNASMN1; SMN2 | |
| SCHEMBL100121 | 0.82 | LOXL2 (0.52) | ALDH1A1TDP1TRPV6LMNASMN1; SMN2 | |
| SCHEMBL23229951 | 0.81 | PRMT6 (0.59) | ALDH1A1KDM4ETRPV6SMN1; SMN2HTT | |
| SCHEMBL10223958 | 0.81 | TRPV6 (0.42) | ALDH1A1KDM4ETDP1TRPV6LMNA | |
| SCHEMBL327459 | 0.80 | KDM4E (0.62) | ALDH1A1KDM4ETDP1SMN1; SMN2HTT | |
| SCHEMBL8243884 | 0.80 | FFAR1 (0.51) | ALDH1A1KDM4ETDP1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148367-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-04-03 | — | — | US | disclosed |
| US-20100105665-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105665-A1 | RENIN INHIBITORS | REN, ACE, AGT | ALDH1A1 947/4885KDM4E 2733/4885TDP1 4131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.