Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CBLB | Q13191 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528120 | 0.91 | LMNA (0.53) | MAPTLMNAHDAC8SMN1; SMN2MEN1 | |
| SCHEMBL529548 | 0.91 | MAPT (0.52) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL528856 | 0.90 | MAPT (0.49) | MAPTLMNAHDAC8SMN1; SMN2MEN1 | |
| SCHEMBL528238 | 0.90 | MAPT (0.59) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL528794 | 0.87 | MAPT (0.62) | MAPTLMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL529226 | 0.86 | SMN1; SMN2 (0.48) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL529437 | 0.86 | MAPT (0.58) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL528124 | 0.85 | KMT2A (0.53) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL528931 | 0.84 | MAPT (0.47) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL528568 | 0.83 | CCR2 (0.47) | MAPTLMNASMN1; SMN2L3MBTL1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |