Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280438 | 1.00 | ITGB3 (0.50) | ITGB3ITGA2BPTPN1MAPTKLK7 | |
| SCHEMBL5284681 | 0.96 | ITGB3 (0.49) | ITGB3ITGA2BPTPN1MAPTACE | |
| SCHEMBL8070826 | 0.89 | ACE (0.53) | ITGB3ITGA2BPTPN1MAPTKLK5 | |
| SCHEMBL5284506 | 0.81 | ITGB3 (0.46) | ITGB3ITGA2BACECTSBCTSS | |
| SCHEMBL4889692 | 0.81 | CTSB (0.47) | ITGB3ITGA2BPTPN1ACECTSB | |
| SCHEMBL7709696 | 0.81 | PTPN1 (0.55) | PTPN1KLK5ACECTSBCTSS | |
| SCHEMBL20905733 | 0.81 | PTPN1 (0.55) | PTPN1KLK5ACECTSBCTSS | |
| SCHEMBL13479127 | 0.79 | CTSS (0.49) | ITGB3MAPTKLK7CTSBCTSS | |
| SCHEMBL17773023 | 0.79 | MAPT (0.66) | ITGB3ITGA2BMAPTKLK7KLK5 | |
| SCHEMBL2552297 | 0.79 | PTPN1 (0.64) | ITGB3ITGA2BPTPN1ACECTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001406-A2 | ARYL-CONTAINING MACROCYCLIC COMPOUNDS | CHIRON CORPORATION (US) | 2007-01-04 | — | — | WO | disclosed |