Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874436 | 0.82 | CCR5 (0.41) | ALOX5ATMALDH1A1KMT2ARAB9A | |
| SCHEMBL5346410 | 0.81 | NNMT (0.42) | ALDH1A1MAPK1KMT2ATDP1RAB9A | |
| SCHEMBL4868910 | 0.74 | ALDH1A1 (0.48) | ALOX5ALDH1A1KMT2ARAB9AMAPT | |
| SCHEMBL11070772 | 0.73 | PAX8 (0.50) | ALOX5ALDH1A1MAPK1TDP1RAB9A | |
| SCHEMBL8561986 | 0.73 | KMT2A (0.55) | ALOX5ALDH1A1PKMKMT2ATDP1 | |
| SCHEMBL5275571 | 0.73 | NOTUM (0.42) | ALDH1A1MAPK1TDP1RAB9AMAPT | |
| SCHEMBL2528439 | 0.73 | ALDH1A1 (0.40) | ALOX5ALDH1A1KMT2ATDP1RAB9A | |
| SCHEMBL29280745 | 0.72 | ALDH1A1 (0.62) | ATMALDH1A1KMT2ATDP1RAB9A | |
| SCHEMBL9299317 | 0.70 | ALDH1A1 (0.51) | ATMALDH1A1PKMKMT2ARAB9A | |
| SCHEMBL3938149 | 0.70 | ALDH1A1 (0.37) | ALDH1A1KMT2ATDP1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851208-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006074950-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |