Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12614854 | 0.98 | CYP3A4 (0.44) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL29337534 | 0.88 | MAPT (0.44) | ATMMAPTMAPK1 | |
| SCHEMBL30567467 | 0.83 | ALDH1A1 (0.52) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL85405 | 0.83 | ALDH1A1 (0.52) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8284590 | 0.80 | CYP3A4 (0.45) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL14349288 | 0.80 | CYP3A4 (0.45) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8181737 | 0.80 | CYP3A4 (0.45) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL20222611 | 0.80 | CYP3A4 (0.45) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL22338921 | 0.80 | CYP3A4 (0.45) | CYP3A4TAAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL933157 | 0.80 | CYP3A4 (0.50) | CYP3A4SLC6A2SLC6A3ATMHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007016190-A2 | ANTIPARKINSONIAN ACTION OF PHENYLISOPROPYLAMINES | DUKE UNIVERSITY (US) | 2007-02-08 | — | — | WO | claimed |
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | claimed |
| US-20150025063-A1 | Antiparkinsonian Action of Phenylisopropylamines | UNIV DUKE (US) | 2015-01-22 | — | — | US | disclosed |
| US-8877802-B2 | Antiparkinsonian action of phenylisopropylamines | Duke Univerity (US) | 2014-11-04 | — | — | US | disclosed |
| WO-2007016190-A2 | ANTIPARKINSONIAN ACTION OF PHENYLISOPROPYLAMINES | DUKE UNIVERSITY (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | disclosed |
| US-6916809-B2 | Heterocyclic acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1456207-A4 | HETEROCYCLIC ACRIDONE INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1456207-A2 | HETEROCYCLIC ACRIDONE INHIBITORS OF IMPDH ENZYME | Bristol-Myers Squibb Company (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20030181497-A1 | Heterocyclic acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-25 | — | — | US | disclosed |
| WO-2003055447-A2 | HETEROCYCLIC ACRIDONE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-10 | — | — | WO | disclosed |
| US-5411965-A | Use of delta opioid receptor antagonists to treat cocaine abuse | ARIZONA BOARD OF REGENTS (US) | 1995-05-02 | — | — | US | disclosed |
| US-4004028-A | BRONCHODILATION | SMITHKLINE CORPORATION (US) | 1977-01-18 | — | — | US | disclosed |
| US-3966770-A | 4-Hydroxy-α-[(3,4-methylenedioxyphenyl)isopropylaminoethyl]-3-(methylsulfonylmethyl)benzyl alcohol | SMITHKLINE CORPORATION (US) | 1976-06-29 | — | — | US | disclosed |
| US-3966770-A | 4-Hydroxy-α-[(3,4-methylenedioxyphenyl)isopropylaminoethyl]-3-(methylsulfonylmethyl)benzyl alcohol | SMITHKLINE CORPORATION (US) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | CYP3A4 1488/4885TAAR1 1075/4885SLC6A4 178/4885 |
| US-20030181497-A1 | Heterocyclic acridone inhibitors of IMPDH enzyme | IMPDH1, IMPDH2, XDH | CYP3A4 288/4885TAAR1 1929/4885SLC6A4 534/4885 |
| US-20150025063-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | CYP3A4 1488/4885TAAR1 1075/4885SLC6A4 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.