Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15190788 | 0.84 | MAPT (0.54) | MAPTEGFRCSF1RALDH1A1HTT | |
| SCHEMBL23575734 | 0.78 | EGFR (0.61) | MAPTEGFRCSF1RALDH1A1HTT | |
| SCHEMBL23575320 | 0.77 | NUDT1 (0.67) | MAPTEGFRCSF1RALDH1A1HTT | |
| SCHEMBL23575595 | 0.76 | PDE4B (0.68) | EGFRCSF1RPDE4B | |
| SCHEMBL9875419 | 0.76 | LMNA (0.54) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9874420 | 0.75 | MEN1 (0.51) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL3785960 | 0.74 | PAX8 (0.52) | MAPTEGFRCSF1RALDH1A1GAA | |
| SCHEMBL13082917 | 0.74 | EGFR (0.61) | MAPTEGFRCSF1RPDE4BMELK | |
| SCHEMBL29220504 | 0.73 | EGFR (0.51) | MAPTEGFRCSF1RALDH1A1HTT | |
| SCHEMBL30864145 | 0.73 | EGFR (0.51) | MAPTEGFRCSF1RALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |