Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | F2R | P25116 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528985 | 0.95 | MAPT (0.54) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL529730 | 0.91 | MAPT (0.58) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL528340 | 0.91 | FFAR1 (0.51) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL528292 | 0.88 | TP53 (0.46) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL529051 | 0.88 | MAPT (0.71) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL529592 | 0.88 | MAPT (0.55) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL528672 | 0.88 | SMO (0.46) | MAPTSMN1; SMN2TP53KDM4EKMT2A | |
| SCHEMBL529438 | 0.87 | MAPT (0.54) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL528514 | 0.86 | L3MBTL1 (0.49) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL528087 | 0.85 | KMT2A (0.55) | MAPTLMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |