Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14822757 | 0.84 | CYP3A4 (0.48) | BRD4HDAC1HTTCYP3A4MAPT | |
| SCHEMBL3806937 | 0.81 | SMN1; SMN2 (0.48) | BRD4TDP1HTTMAPTGAA | |
| SCHEMBL14610740 | 0.81 | GAA (0.44) | BRD4TDP1HDAC1HDAC6HTT | |
| SCHEMBL14822759 | 0.81 | RIPK1 (0.44) | BRD4HDAC1HDAC6HTTCYP3A4 | |
| SCHEMBL14822756 | 0.76 | CYP3A4 (0.44) | BRD4HTTCYP3A4MAPTGAA | |
| SCHEMBL14610743 | 0.75 | ALDH1A1 (0.44) | CYP3A4L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL752119 | 0.73 | MAPT (0.60) | TDP1HDAC1HDAC6HTTMAPT | |
| SCHEMBL31172687 | 0.73 | BRD4 (0.42) | BRD4TDP1HDAC1HDAC6HTT | |
| SCHEMBL1459408 | 0.72 | HTT (0.59) | HDAC1HDAC6HTTMAPTGAA | |
| SCHEMBL30046619 | 0.72 | HTT (0.59) | HDAC1HDAC6HTTMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |