SCHEMBL530145

SCHEMBL530145

O=C(O)c1cc(C(=O)O)c(N2C(=O)CCC2=O)c(C(=O)O)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.52
CA1 P00915 3/20 0.52
CA9 Q16790 3/20 0.52
GAA P10253 1/20 0.41
NSD2 O96028 1/20 0.40
G6PD P11413 1/20 0.40
KEAP1 Q14145 1/20 0.40
NFE2L2 Q16236 1/20 0.40
KMT2A Q03164 2/20 0.40
ALDH1A1 P00352 4/20 0.39
MAPK1 P28482 2/20 0.39
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HSD17B10 Q99714 3/20 0.36
CA2 P00918 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31530993 0.75 MAOB (0.40) CA12CA1CA9GAAKMT2A
SCHEMBL16875695 0.75 CA1 (0.39) CA12CA1CA9GAAKMT2A
SCHEMBL16875692 0.74 CA12 (0.38) CA12CA1CA9GAAKEAP1
SCHEMBL16875693 0.73 KMT2A (0.35) CA12CA1CA9KMT2AALDH1A1
SCHEMBL16875682 0.73 AKR1C3 (0.36) CA12CA1CA9KMT2AALDH1A1
Hydrochloric Acid SCHEMBL29229585 0.72 ALDH1A1 (0.45) CA12CA1CA9GAAKMT2A
SCHEMBL529829 0.70 CA12 (0.47) CA12CA1CA9GAAKMT2A
SCHEMBL458085 0.68 CA12 (1.00) CA12CA1CA9KMT2AALDH1A1
SCHEMBL317655 0.68 ALB (0.49) CA12CA1CA9GAAKMT2A
SCHEMBL317764 0.68 CA12 (0.42) CA12CA1CA9KEAP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199695-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY TRANSFERT PLUS, S.E.C. (CA) 2024-06-20 US disclosed
US-20240156971-A1 METHODS AND SORTILIN BINDING CONJUGATE COMPOUNDS FOR TARGETING CANCER STEM CELLS TRANSFERT PLUS, SOCIÉTÉ EN COMMANDITE (CA) 2024-05-16 US disclosed
US-11780882-B2 Peptide compounds and peptide conjugates for the treatment of cancer through receptor-mediated chemotherapy TRANSFERT PLUS, S.E.C. (CA) 2023-10-10 US disclosed
US-20230036041-A1 SORTILIN BINDING CONJUGATE COMPOUNDS, COMPOSITIONS AND USES THEREOF FOR TREATING CANCER THERATECHNOLOGIES INC. (CA) 2023-02-02 US disclosed
US-20220356209-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY TRANSFERT PLUS, S.E.C. (CA) 2022-11-10 US disclosed
US-20220000971-A1 METHODS AND COMPOUNDS FOR TARGETING SORTILIN RECEPTORS AND INHIBITING VASCULOGENIC MIMICRY TRANSFERT PLUS, S.E.C. (CA) 2022-01-06 US disclosed
US-11034727-B2 Peptide compounds and peptide conjugates for the treatment of cancer through receptor-mediated chemotherapy TRANSFERT PLUS, S.E.C. (CA) 2021-06-15 US disclosed
US-20200392184-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY THERATECHNOLOGIES INC. (CA) 2020-12-17 US disclosed
US-20200157151-A1 PEPTIDE COMPOUNDS, CONJUGATE COMPOUNDS AND USES THEREOF FOR TREATING INFLAMMATORY DISEASES TRANSFERT PLUS, S.E.C. (CA) 2020-05-21 US disclosed
US-20170326233-A1 CONJUGATES INCLUDING AN ANTIBODY MOIETY, A POLYPEPTIDE THAT TRAVERSES THE BLOOD-BRAIN BARRIER, AND A CYTOTOXIN ANGIOCHEM INC (CA) 2017-11-16 US disclosed
US-20170281787-A1 CONJUGATES INCLUDING AN ANTIBODY MOIETY, A POLYPEPTIDE THAT TRAVERSES THE BLOOD-BRAIN BARRIER, AND A CYTOTOXIN ANGIOCHEM INC (CA) 2017-10-05 US disclosed
EP-2885318-A1 PEPTIDE-DENDRIMER CONJUGATES AND USES THEREOF Angiochem Inc. (CA) 2015-06-24 EP disclosed
WO-2014026283-A1 PEPTIDE-DENDRIMER CONJUGATES AND USES THEREOF ANGIOCHEM INC. (CA) 2014-02-20 WO disclosed
EP-2598522-A2 RECOMBINANT LECTINS, BINDING-SITE MODIFIED LECTINS AND USES THEREOF Smartcells, Inc. (US) 2013-06-05 EP disclosed
WO-2012015691-A2 RECOMBINANT LECTINS, BINDING-SITE MODIFIED LECTINS AND USES THEREOF SMARTCELLS, INC. (US) 2012-02-02 WO disclosed
EP-2391216-A1 EXOGENOUSLY TRIGGERED CONTROLLED RELEASE MATERIALS AND USES THEREOF Smartcells, Inc. (US) 2011-12-07 EP disclosed
EP-2391215-A1 BINDING-SITE MODIFIED LECTINS AND USES THEREOF Smartcells, Inc. (US) 2011-12-07 EP disclosed
WO-2010088276-A2 POLYNUCLEOTIDE APTAMER-BASED CROSS -LINKED MATERIALS AND USES THEREOF SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
WO-2010088261-A1 BINDING-SITE MODIFIED LECTINS AND USES THEREOF SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
WO-2010088268-A1 EXOGENOUSLY TRIGGERED CONTROLLED RELEASE MATERIALS AND USES THEREOF SMARTCELLS, INC. (US) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392184-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY NGLY1, GNRHR, GRPR CA12 3434/4885CA1 4394/4885CA9 1743/4885
US-20230036041-A1 SORTILIN BINDING CONJUGATE COMPOUNDS, COMPOSITIONS AND USES THEREOF FOR TREATING CANCER SORT1, NGLY1, SNX9 CA12 2805/4885CA1 4442/4885CA9 413/4885
US-20240199695-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY NGLY1, VIP, NPY1R CA12 2389/4885CA1 3544/4885CA9 381/4885
US-20170326233-A1 CONJUGATES INCLUDING AN ANTIBODY MOIETY, A POLYPEPTIDE THAT TRAVERSES THE BLOOD-BRAIN BARRIER, AND A CYTOTOXIN VIP, KLKB1, SERPINA3 CA12 734/4885CA1 629/4885CA9 1417/4885
US-11034727-B2 Peptide compounds and peptide conjugates for the treatment of cancer through receptor-mediated chemotherapy NGLY1, GNRHR, GRPR CA12 3434/4885CA1 4394/4885CA9 1743/4885
US-20240156971-A1 METHODS AND SORTILIN BINDING CONJUGATE COMPOUNDS FOR TARGETING CANCER STEM CELLS SORT1, CD44, SCARB1 CA12 1468/4885CA1 3371/4885CA9 2035/4885
US-20170281787-A1 CONJUGATES INCLUDING AN ANTIBODY MOIETY, A POLYPEPTIDE THAT TRAVERSES THE BLOOD-BRAIN BARRIER, AND A CYTOTOXIN VIP, KLKB1, ADAM17 CA12 810/4885CA1 650/4885CA9 1438/4885
US-20220000971-A1 METHODS AND COMPOUNDS FOR TARGETING SORTILIN RECEPTORS AND INHIBITING VASCULOGENIC MIMICRY SORT1, FLT1, FLT4 CA12 2092/4885CA1 4120/4885CA9 228/4885
US-20220356209-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY NGLY1, VIP, NPY1R CA12 2284/4885CA1 3469/4885CA9 263/4885
US-11780882-B2 Peptide compounds and peptide conjugates for the treatment of cancer through receptor-mediated chemotherapy NGLY1, VIP, NPY1R CA12 2269/4885CA1 3461/4885CA9 314/4885
US-20200157151-A1 PEPTIDE COMPOUNDS, CONJUGATE COMPOUNDS AND USES THEREOF FOR TREATING INFLAMMATORY DISEASES VIP, TNFRSF9, TNFRSF1A CA12 4352/4885CA1 4509/4885CA9 3016/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.