Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317655 | 0.80 | ALB (0.49) | CA12CA1CA9ALDH1A1ALOX15 | |
| SCHEMBL1834310 | 0.79 | CA12 (0.41) | CA12CA1CA9ALDH1A1TP53 | |
| SCHEMBL15636976 | 0.78 | ALDH1A1 (0.43) | CA12CA1CA9ALDH1A1ALOX15 | |
| SCHEMBL31530993 | 0.77 | MAOB (0.40) | CA12CA1CA9ALDH1A1TP53 | |
| SCHEMBL4901236 | 0.76 | TLR9 (0.49) | CA12CA1CA9ALDH1A1ALOX15 | |
| SCHEMBL334907 | 0.76 | CA12 (0.39) | CA12CA1CA9ALDH1A1ALOX15 | |
| SCHEMBL6006263 | 0.75 | TSHR (0.56) | ALDH1A1KMT2ATSHRL3MBTL1MEN1 | |
| SCHEMBL28755352 | 0.73 | TLR9 (0.45) | CA12CA1CA9ALDH1A1ALOX15 | |
| SCHEMBL3678196 | 0.73 | NPC1 (0.48) | CA12CA1CA9ALDH1A1ALOX15 | |
| SCHEMBL9262225 | 0.72 | GAA (0.55) | CA12CA1CA9ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12023389-B2 | Compositions that target tumor-associated macrophages and methods of use therefor | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-07-02 | — | — | US | disclosed |
| US-20240131201-A1 | COMPOSITIONS THAT TARGET TUMOR-ASSOCIATED MACROPHAGES AND METHODS OF USE THEREFOR | Sanford Burnham Prebys Medical Discovery Institute | 2024-04-25 | — | — | US | disclosed |
| US-11571484-B2 | Compositions that target tumor-associated macrophages and methods of use therefor | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-02-07 | — | — | US | disclosed |
| US-20200268910-A1 | COMPOSITIONS THAT TARGET TUMOR-ASSOCIATED MACROPHAGES AND METHODS OF USE THEREFOR | Sanford Burnham Prebys Medical Discovery Institute | 2020-08-27 | — | — | US | disclosed |
| EP-3687559-A2 | COMPOSITIONS THAT TARGET TUMOR-ASSOCIATED MACROPHAGES AND METHODS OF USE THEREFOR | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-08-05 | — | — | EP | disclosed |
| EP-2903629-B1 | ANTIBODY CONJUGATE FOR USE IN TREATING INFLAMMATORY BOWEL DISEASE | PHILOGEN SPA (IT) | 2019-07-10 | — | — | EP | disclosed |
| WO-2019067984-A2 | COMPOSITIONS THAT TARGET TUMOR-ASSOCIATED MACROPHAGES AND METHODS OF USE THEREFOR | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-04-04 | — | — | WO | disclosed |
| US-10239939-B2 | Anti-ED-A immunoconjugates for inflammatory bowel disease | PHILOGEN S.P.A. (IT) | 2019-03-26 | — | — | US | disclosed |
| US-20180044408-A1 | ANTIGENS ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE | PHILOGEN SPA (IT) | 2018-02-15 | — | — | US | disclosed |
| US-9695232-B2 | Anti-ED-A immunoconjugates for inflammatory bowel disease | PHILOGEN S.P.A. (IT) | 2017-07-04 | — | — | US | disclosed |
| EP-2495563-A1 | DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES | Fujifilm RI Pharma Co., Ltd. (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20120219500-A1 | DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES | FUJIFILM RI PHARMA CO., LTD. (JP) | 2012-08-30 | — | — | US | disclosed |
| US-8093405-B2 | Formation of 18F and 19F fluoroarenes bearing reactive functionalities | UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2012-01-10 | — | — | US | disclosed |
| CN-102300842-A | Radioiodination method | — | 2011-12-28 | — | — | CN | disclosed |
| US-20110280803-A1 | RADIOIODINATION METHOD | GE HEALTHCARE UK LIMITED (GB) | 2011-11-17 | — | — | US | disclosed |
| EP-2382185-A1 | RADIOIODINATION METHOD | GE Healthcare Limited (GB) | 2011-11-02 | — | — | EP | disclosed |
| EP-2310362-A1 | FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES | University Of Newcastle-Upon Tyne (GB) | 2011-04-20 | — | — | EP | disclosed |
| WO-2010086398-A1 | RADIOIODINATION METHOD | GE HEALTHCARE LIMITED (GB) | 2010-08-05 | — | — | WO | disclosed |
| WO-2009138763-A1 | FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES | UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-11-19 | — | — | WO | disclosed |
| US-20090286992-A1 | FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES | UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110280803-A1 | RADIOIODINATION METHOD | TPO, SSTR5, DAO | CA12 407/4885CA1 426/4885CA9 245/4885 |
| US-20090286992-A1 | FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES | RARB, RARG, RARA | CA12 316/4885CA1 638/4885CA9 1392/4885 |
| US-20120219500-A1 | DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES | NISCH, CNDP2, MYADM | CA12 1889/4885CA1 3891/4885CA9 1490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.