Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.41 |
| ▸ | GALR1 | P47211 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL7878195 | 0.85 | MAPK14 (0.46) | MAPK14CHRNA10CHRNA9GALR1HPGD | |
| Morpholine SCHEMBL548401 | 0.80 | MAPK14 (0.44) | MAPK14CHRNA10CHRNA9GALR1CD274 | |
| Morpholine SCHEMBL5963675 | 0.79 | MAPK14 (0.43) | MAPK14CHRNA10CHRNA9GALR1CD274 | |
| Dimethylamine SCHEMBL4448304 | 0.76 | MAPK14 (0.44) | MAPK14HPGDKMT2ARIPK1CYP2D6 | |
| Morpholine SCHEMBL5483585 | 0.76 | OPRD1 (0.41) | MAPK14CHRNA10CHRNA9GALR1CD274 | |
| SCHEMBL13918749 | 0.68 | KDM4E (0.70) | CHRNA10CHRNA9KMT2AKDM4EDRD2 | |
| Morpholine SCHEMBL28644462 | 0.68 | LMNA (0.52) | CD274HPGDKMT2AKDM4EOPRD1 | |
| SCHEMBL1928092 | 0.65 | L3MBTL1 (0.68) | MAPK14KMT2AKDM4EDRD2DRD4 | |
| SCHEMBL1927649 | 0.65 | DRD2 (0.77) | HPGDKMT2AKDM4EDRD2DRD4 | |
| SCHEMBL1926646 | 0.64 | HIF1A (0.56) | MAPK14HPGDKMT2AKDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |