Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361085 | 0.87 | TSHR (0.42) | SMN1; SMN2TSHRKDM4CRORCKDM4E | |
| SCHEMBL27713903 | 0.86 | KDM4C (0.43) | NPC1KDM4CRORC | |
| SCHEMBL14361090 | 0.84 | HPGD (0.45) | SMN1; SMN2KDM4CKDM4EALDH1A1GAA | |
| SCHEMBL14360940 | 0.84 | ALDH1A1 (0.42) | SMN1; SMN2TSHRKDM4EALDH1A1GAA | |
| SCHEMBL14360962 | 0.82 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2NPC1TSHRALDH1A1 | |
| SCHEMBL27693955 | 0.82 | OPRM1 (0.43) | NPC1KDM4C | |
| SCHEMBL14360961 | 0.81 | MEN1 (0.50) | RAB9ASMN1; SMN2NPC1TSHRKDM4E | |
| SCHEMBL5303414 | 0.81 | TYK2 (0.49) | CYP3A4RAB9ASMN1; SMN2NPC1KDM4C | |
| SCHEMBL5436150 | 0.80 | KDM4E (0.43) | CYP3A4RAB9ASMN1; SMN2NPC1KDM4C | |
| SCHEMBL14360923 | 0.78 | RAB9A (0.50) | CYP3A4RAB9ASMN1; SMN2NPC1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101098857-A | Nitro indazole derivatives | ASTRAZENECA AB (SE) | 2008-01-02 | — | — | CN | disclosed |
| US-20070265325-A1 | Nitro Indazole Derivatives | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | US | disclosed |
| US-20070265325-A1 | Nitro Indazole Derivatives | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | US | disclosed |
| US-20070265325-A1 | Nitro Indazole Derivatives | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | US | disclosed |
| EP-1814864-A1 | NITRO INDAZOLE DERIVATIVES | AstraZeneca AB (SE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052189-A1 | NITRO INDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265325-A1 | Nitro Indazole Derivatives | NOS3, CYP3A43, NOS2 | CYP3A4 4/4885RAB9A 1965/4885SMN1; SMN2 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.