Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.54 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423786 | 0.84 | ALOX5 (0.61) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL17917597 | 0.81 | ADORA2A (0.54) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL20152951 | 0.81 | ERN1 (0.50) | BACE1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL28402503 | 0.80 | ALDH1A1 (0.44) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL28293173 | 0.79 | BACE1 (0.71) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL344800 | 0.79 | BACE1 (0.71) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL29485605 | 0.79 | BACE1 (0.71) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL3314589 | 0.79 | BACE1 (0.44) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL13445421 | 0.79 | BACE1 (0.44) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL1754202 | 0.78 | BACE1 (1.00) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460111-B1 | PREPARATION OF 4-SUBSTITUTED ARYL OLEFINS | EASTMAN KODAK CO (US) | 1993-12-08 | — | — | EP | claimed |
| EP-0460111-A1 | PREPARATION OF 4-SUBSTITUTED ARYL OLEFINS. | EASTMAN KODAK CO (US) | 1991-12-11 | — | — | EP | claimed |
| EP-0406310-A1 | PROCESS FOR THE CARBONYLATION OF IODOAROMATIC COMPOUNDS. | EASTMAN KODAK CO (US) | 1991-01-09 | — | — | EP | claimed |
| US-4965361-A | CATALYTIC REACTION OF 4-SUBSTITUTED ARYL IODIDE WITH OLEFIN IN ESTER SOLVENT | EASTMAN KODAK COMPANY (US) | 1990-10-23 | — | — | US | claimed |
| EP-0388322-A1 | Preparation of 4-substituted aryl olefins | EASTMAN KODAK COMPANY (US) | 1990-09-19 | — | — | EP | claimed |
| WO-1990009973-A1 | PREPARATION OF 4-SUBSTITUTED ARYL OLEFINS | EASTMAN KODAK COMPANY (US) | 1990-09-07 | — | — | WO | claimed |
| US-4885384-A | USING PALLADIUM CATALYST AND BRONSTED BASE | STATE STREET BANK AND TRUST COMPANY | 1989-12-05 | — | — | US | claimed |
| WO-1989008634-A1 | PROCESS FOR THE CARBONYLATION OF IODOAROMATIC COMPOUNDS | EASTMAN KODAK COMPANY (US) | 1989-09-21 | — | — | WO | claimed |
| CN-101268072-A | DNA-PK inhibitors | KUDOS PHARM LTD (GB) | 2008-09-17 | — | — | CN | disclosed |
| EP-1869040-A1 | DNA-PK INHIBITORS | Kudos Pharmaceuticals Ltd (GB) | 2007-12-26 | — | — | EP | disclosed |
| US-20060264623-A1 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-11-23 | — | — | US | disclosed |
| WO-2006109084-A1 | DNA-PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |
| EP-0460111-B1 | PREPARATION OF 4-SUBSTITUTED ARYL OLEFINS | EASTMAN KODAK CO (US) | 1993-12-08 | — | — | EP | disclosed |
| EP-0377638-B1 | PROCESS FOR THE IODINATION OF HYDROXYAROMATIC AND AMINOAROMATIC COMPOUNDS | EASTMAN KODAK COMPANY (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0460111-A1 | PREPARATION OF 4-SUBSTITUTED ARYL OLEFINS. | EASTMAN KODAK CO (US) | 1991-12-11 | — | — | EP | disclosed |
| US-4965361-A | CATALYTIC REACTION OF 4-SUBSTITUTED ARYL IODIDE WITH OLEFIN IN ESTER SOLVENT | EASTMAN KODAK COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0388322-A1 | Preparation of 4-substituted aryl olefins | EASTMAN KODAK COMPANY (US) | 1990-09-19 | — | — | EP | disclosed |
| WO-1990009973-A1 | PREPARATION OF 4-SUBSTITUTED ARYL OLEFINS | EASTMAN KODAK COMPANY (US) | 1990-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264623-A1 | DNA-PK inhibitors | TOP2B, TOP2A, POLN | BACE1 3323/4885ALDH1A1 2579/4885HPGD 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.