Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | CCR9 | P51686 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314252 | 0.91 | PTGDR2 (0.47) | PTGDR2CA12CA1CA2CA9 | |
| SCHEMBL5312598 | 0.90 | PTGDR2 (0.55) | PTGDR2AKR1C3AKR1C2AKR1B1CCR9 | |
| SCHEMBL5307807 | 0.89 | PTGDR2 (0.50) | PTGDR2AKR1C3AKR1C2CA12CA1 | |
| SCHEMBL5311262 | 0.88 | PTGDR2 (0.47) | PTGDR2CA12CA1CA2CA9 | |
| SCHEMBL5310070 | 0.86 | CA12 (0.43) | PTGDR2CA12CA1CA2CA9 | |
| SCHEMBL5312658 | 0.85 | MAPT (0.51) | PTGDR2CA12CA1CA2CA9 | |
| SCHEMBL5313784 | 0.85 | USP2 (0.45) | PTGDR2CA12CA1CA2CA9 | |
| SCHEMBL5310476 | 0.82 | ALDH1A1 (0.46) | PTGDR2AKR1C3AKR1C2CA12CA1 | |
| SCHEMBL5310742 | 0.80 | PTGDR2 (0.60) | PTGDR2AKR1B1FLT1FLT4KDR | |
| SCHEMBL5313192 | 0.80 | PTGDR2 (0.48) | PTGDR2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007045867-A1 | 3 -AMINOINDOLE COMPOUNDS AS CRTH2 RECEPTOR LIGANDS | ARGENTA DISCOVERY LIMITED (GB) | 2007-04-26 | — | — | WO | disclosed |