Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | TACR3 | P29371 | 1/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5926435 | 0.91 | MEN1 (0.63) | MEN1POLBKMT2AALDH1A1ROCK2 | |
| SCHEMBL3994922 | 0.88 | CTSA (0.56) | KMT2AALDH1A1UTS2RCTSLCTSB | |
| SCHEMBL5691953 | 0.87 | CTSB (0.48) | MEN1POLBKMT2AALDH1A1UTS2R | |
| SCHEMBL5692537 | 0.85 | MEN1 (0.49) | MEN1POLBKMT2AALDH1A1UTS2R | |
| SCHEMBL4824606 | 0.84 | ROCK2 (0.52) | MEN1POLBKMT2AALDH1A1ROCK2 | |
| SCHEMBL5927665 | 0.82 | POLB (0.53) | MEN1POLBKMT2AALDH1A1ROCK2 | |
| SCHEMBL3972848 | 0.81 | POLB (0.53) | MEN1POLBKMT2AALDH1A1ROCK2 | |
| SCHEMBL5693091 | 0.81 | UTS2R (0.47) | MEN1KMT2AUTS2R | |
| SCHEMBL5691904 | 0.81 | MMP12 (0.47) | MEN1POLBKMT2AALDH1A1CTSL | |
| SCHEMBL14198862 | 0.80 | MEN1 (0.63) | MEN1POLBKMT2AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185204-A1 | Crystalline forms of 3-biphenyl-4-yl-(2S)-[(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid, and methods of use | TRANSTECH PHARMA, INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2007087148-A1 | CRYSTALLINE FORMS OF 3-BIPHENYL-4-YL-(2S)-[(4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-PROPIONIC ACID, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007044574-A2 | PHARMACEUTICAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND METHODS OF TREATMENT | TRANSTECH PHARMA, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082952-A1 | Pharmaceutical compositions, methods of preparation thereof, and methods of treatment | TRANSTECH PHARMA, INC. | 2007-04-12 | — | — | US | disclosed |