Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.44 |
| ▸ | TXK | P42681 | 1/20 | 0.44 |
| ▸ | BMX | P51813 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226243 | 0.85 | KEAP1 (0.61) | KEAP1NFE2L2KMT2AFFAR4KDM4E | |
| SCHEMBL1127360 | 0.84 | KMT2A (0.65) | KMT2AKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5227771 | 0.82 | FFAR4 (0.68) | KEAP1NFE2L2KMT2AFFAR4KDM4E | |
| SCHEMBL31481384 | 0.79 | KDM4E (0.50) | KMT2AKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL13450268 | 0.79 | KDM4E (0.50) | KMT2AKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL3378177 | 0.78 | ALDH1A1 (0.47) | KEAP1NFE2L2KMT2AKDM4EALDH1A1 | |
| SCHEMBL15387043 | 0.77 | KDM4E (0.49) | KMT2AKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL530856 | 0.77 | ACLY (0.47) | KEAP1NFE2L2KMT2AALDH1A1TSHR | |
| SCHEMBL18548833 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2KMT2AKDM4EALDH1A1 | |
| SCHEMBL16305428 | 0.76 | SIRT2 (0.55) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | claimed |
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |