Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788749 | 0.82 | TSHR (0.51) | ACLYKEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL10554673 | 0.80 | DRD2 (0.50) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL10391939 | 0.80 | KEAP1 (0.61) | KEAP1NFE2L2ALDH1A1POLBKMT2A | |
| SCHEMBL3378185 | 0.80 | L3MBTL1 (0.41) | KEAP1NFE2L2ALDH1A1IKBKBCHUK | |
| SCHEMBL27291130 | 0.80 | ACLY (0.47) | ACLYKEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL11742028 | 0.79 | DRD2 (0.49) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL20355553 | 0.79 | DRD2 (0.53) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL30409645 | 0.77 | DRD2 (0.51) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL3378188 | 0.77 | SIRT1 (0.39) | ALDH1A1IKBKBCHUKKMT2A | |
| SCHEMBL530858 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | claimed |
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |