Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCPS | Q96C86 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 7/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851533 | 0.72 | PI4KA (0.48) | MAP4K4ALDH1A1CYP1A2HSD17B10KDM4E | |
| SCHEMBL4843211 | 0.68 | PDPK1 (0.36) | DHFRALDH1A1KDM4E | |
| SCHEMBL22116570 | 0.67 | L3MBTL1 (0.34) | ALDH1A1CYP1A2KDM4E | |
| SCHEMBL29375878 | 0.66 | DCPS (1.00) | DCPSDHFRALDH1A1CYP1A2HPGD | |
| SCHEMBL269636 | 0.66 | DCPS (1.00) | DCPSDHFRALDH1A1CYP1A2HPGD | |
| SCHEMBL1069166 | 0.64 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL27509781 | 0.64 | NCF1 (0.48) | ALDH1A1HPGDHSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL6601650 | 0.64 | DCPS (0.95) | DCPSDHFRALDH1A1CYP1A2HPGD | |
| SCHEMBL30468763 | 0.64 | DCPS (0.95) | DCPSDHFRALDH1A1CYP1A2HPGD | |
| Hydrochloric Acid SCHEMBL27786605 | 0.64 | DCPS (0.95) | DCPSDHFRALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773817-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012374-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-02-02 | — | — | WO | disclosed |