Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 4/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21571314 | 0.76 | CYP2A6 (0.35) | — | |
| SCHEMBL5312566 | 0.72 | DCPS (0.48) | KDM4EMAP4K4ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9341222 | 0.72 | POLB (0.39) | LRRK2CHEK1AURKAPRKACARPS6KA3 | |
| SCHEMBL5551347 | 0.72 | MAP4K4 (0.40) | KDM4EMAP4K4CSF1RCLK4MEN1 | |
| SCHEMBL5658693 | 0.69 | NOS3 (0.50) | PI4KAPI4K2BPI4K2API4KBKDM4E | |
| SCHEMBL3956713 | 0.68 | ALDH1A1 (0.38) | KDM4EAURKAAURKBDYRK1BMEN1 | |
| SCHEMBL17442625 | 0.68 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLIMK1 | |
| SCHEMBL22116851 | 0.67 | KDM4E (0.34) | KDM4EPLAUALDH1A1CYP1A2 | |
| 4-Aminoquinazoline SCHEMBL142513 | 0.66 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLIMK1 | |
| 4-Aminoquinazoline SCHEMBL29363315 | 0.66 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390907-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20050153984-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153984-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV2, TRPV3 | PI4KA 2127/4885PI4K2B 2986/4885PI4K2A 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.